Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010503)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant ACU-5116 Product ACU-5145
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010499 Emixustat ACU-5116 Oxidation - Oxidative Deamination Emixustat [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010500 ACU-5116 ACU-5124 Oxidation - Hydroxylation Emixustat [1], [2]
MR010502 ACU-5116 ACU-5144 Oxidation - Hydroxylation Emixustat [1], [2]
MR010501 ACU-5116 ACU-5149 Oxidation - Hydroxylation Emixustat [1], [2]
MR010504 ACU-5116 ACU-5188 Oxidation - Dehydrogenation Hydroxylation Emixustat [1], [2]
References
1 Oxidative Deamination of Emixustat by Human Vascular Adhesion Protein-1/Semicarbazide-Sensitive Amine Oxidase
2 Disposition, profiling and identification of emixustat and its metabolites in humans

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