Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010509)
Formula Reactant Emixustat Product Emixustat Metabolite M20
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010506 Emixustat ACU-4861 Oxidation - Hydroxylation Emixustat [1], [2]
MR010507 Emixustat ACU-4949 Oxidation - Hydroxylation Emixustat [1], [2]
MR010508 Emixustat ACU-4982 Oxidation - Hydroxylation Emixustat [1], [2]
MR010499 Emixustat ACU-5116 Oxidation - Oxidative Deamination Emixustat [1], [2]
MR010510 Emixustat Emixustat Metabolite M11 Multi-steps Reaction - Hydroxylation; Dehydrogenation Emixustat [1], [2]
MR010505 Emixustat Emixustat Metabolite M3 Multi-steps Reaction - Hydroxylation; Glucuronidation Emixustat [1], [2]
References
1 Oxidative Deamination of Emixustat by Human Vascular Adhesion Protein-1/Semicarbazide-Sensitive Amine Oxidase
2 Disposition, profiling and identification of emixustat and its metabolites in humans

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