Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010627)
Formula
SVG example
N-Desmethylation
Reactant Cyclizine Product Norcyclizine
Reactant Info Product Info
Metabolic Type Oxidation - N-Desmethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010629 Cyclizine Monohydroxycyclizine Oxidation - Aromatic Hydroxylation Cyclizine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013303 Cinnarizine Cinnarizine metabolite M1 Unclear Cinnarizine [2]
MR010646 Sumatriptan Indo-3-yl-acetaldehyde derivative Unclear - Unclear Sumatriptan [3]
MR010642 N-Desmethyl sumatriptan Indo-3-yl-acetaldehyde derivative Unclear - Unclear Sumatriptan [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010628 Norcyclizine Hydroxynorcyclizine Oxidation - Heterocyclic Ring Hydroxylation Cyclizine [1]
MR010643 Indo-3-yl-acetaldehyde derivative Indo-3-yl-acetic acid derivative Unclear - Unclear Sumatriptan [3]
References
1 Biotransformation of cyclizine in greyhounds. 1: Identification and analysis of cyclizine and some basic metabolites in canine urine by gas chromatography-mass spectrometry
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Metabolism of sumatriptan revisited

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.