Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013303)
Formula
CYP2C9 ...
SVG example
Reactant Cinnarizine Product Cinnarizine metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013307 Cinnarizine 1-Cinnamylpiperazine Oxidation - N-dealkylation; hydrolysis Cinnarizine [1]
MR013306 Cinnarizine Cinnamaldehyde Oxidation - N-dealkylation Cinnarizine [1]
MR013304 Cinnarizine Cinnarizine metabolite M2 Oxidation - Hydrolyzationn Cinnarizine [2]
MR013305 Cinnarizine Cinnarizine metabolite M4 Oxidation - Hydrolyzationn Cinnarizine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010627 Cyclizine Norcyclizine Oxidation - N-Desmethylation Cyclizine [3]
MR010646 Sumatriptan Indo-3-yl-acetaldehyde derivative Unclear - Unclear Sumatriptan [4]
MR010642 N-Desmethyl sumatriptan Indo-3-yl-acetaldehyde derivative Unclear - Unclear Sumatriptan [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010628 Norcyclizine Hydroxynorcyclizine Oxidation - Heterocyclic Ring Hydroxylation Cyclizine [3]
MR010643 Indo-3-yl-acetaldehyde derivative Indo-3-yl-acetic acid derivative Unclear - Unclear Sumatriptan [4]
References
1 DrugBank : Cinnarizine
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Biotransformation of cyclizine in greyhounds. 1: Identification and analysis of cyclizine and some basic metabolites in canine urine by gas chromatography-mass spectrometry
4 Metabolism of sumatriptan revisited

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