Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010628)
Formula Reactant Norcyclizine Product Hydroxynorcyclizine
Reactant Info Product Info
Metabolic Type Oxidation - Heterocyclic Ring Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013303 Cinnarizine Cinnarizine metabolite M1 Unclear Cinnarizine [1]
MR010627 Cyclizine Norcyclizine Oxidation - N-Desmethylation Cyclizine [2]
MR010646 Sumatriptan Indo-3-yl-acetaldehyde derivative Unclear - Unclear Sumatriptan [3]
MR010642 N-Desmethyl sumatriptan Indo-3-yl-acetaldehyde derivative Unclear - Unclear Sumatriptan [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010643 Indo-3-yl-acetaldehyde derivative Indo-3-yl-acetic acid derivative Unclear - Unclear Sumatriptan [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Biotransformation of cyclizine in greyhounds. 1: Identification and analysis of cyclizine and some basic metabolites in canine urine by gas chromatography-mass spectrometry
3 Metabolism of sumatriptan revisited

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