Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010688)
Formula
CYP3A4 ...
SVG example
Unclear
Reactant Levallorphan Product Levallorphan Metabolite M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010684 Levallorphan Levallorphan Metabolite M7 Unclear - Unclear Levallorphan [1]
MR010686 Levallorphan Levallorphan Metabolite M8 Unclear - Unclear Levallorphan [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010613 Levorphanol Levorphanol Metabolite M6 Unclear - Unclear Levorphanol [1]
MR000816 (+)-3-Methoxymorphinan 3-hydroxymorphinan Oxidation - O-Demethylation Dextromethorphan hydrobromide [2]
MR000811 Dextrorphan 3-hydroxymorphinan Oxidation - N-Demethylation Dextromethorphan hydrobromide [3], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010689 Levallorphan Metabolite M4 Levallorphan Metabolite M11 Unclear - Unclear Levallorphan [1]
MR010614 Levorphanol Metabolite M6 Levorphanol Metabolite M7 Unclear - Unclear Levorphanol [1]
MR000815 3-hydroxymorphinan 3-hydroxymorphinan O-glucuronide Conjugation - Glucuronidation Dextromethorphan hydrobromide [2], [4]
MR000814 3-hydroxymorphinan 3-hydroxymorphinan sulfate Conjugation - Sulfation Dextromethorphan hydrobromide [3]
References
1 Exploration of catalytic properties of CYP2D6 and CYP3A4 through metabolic studies of levorphanol and levallorphan
2 LC-MS/MS analysis of dextromethorphan metabolism in human saliva and urine to determine CYP2D6 phenotype and individual variability in N-demethylation and glucuronidation J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 25;813(1-2):217-25. doi: 10.1016/j.jchromb.2004.09.040.
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
4 Classics in Chemical Neuroscience: Dextromethorphan (DXM). ACS Chem Neurosci. 2023 Jun 21;14(12):2256-2270. doi: 10.1021/acschemneuro.3c00088.

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