Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010806)
Formula	Unclear
	Reactant	3-keto-Delta4-Abiraterone(D4A)	Product	3-keto-5alpha-Abiraterone
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Unclear - Unclear

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR010805	ABIRATERONE	3-keto-Delta4-Abiraterone(D4A)	Unclear - Unclear	ABIRATERONE	[1]
MR000014	Abiraterone acetate	D4A	Oxidation - Dehydrogenation	Abiraterone acetate	[2]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR010807	3-keto-Delta4-Abiraterone(D4A)	3-keto-5beta-Abiraterone	Unclear - Unclear	ABIRATERONE	[1]

References
1	The interactions of a number of steroid-metabolizing cytochromes P450 with abiraterone D4A metabolite: spectral analysis and molecular docking
2	Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer Nature. 2015 Jul 16;523(7560):347-51. doi: 10.1038/nature14406.

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