Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000014)
Formula
SVG example
Dehydrogenation
Reactant Abiraterone acetate Product D4A
Reactant Info Product Info
Metabolic Enzyme Dihydrotestosterone oxidoreductase (HSD3B1) DME Info
Metabolic Type Oxidation - Dehydrogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000013 Abiraterone acetate Abiraterone Hydrolysis - Hydrolysis Abiraterone acetate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010805 ABIRATERONE 3-keto-Delta4-Abiraterone(D4A) Unclear - Unclear ABIRATERONE [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010806 3-keto-Delta4-Abiraterone(D4A) 3-keto-5alpha-Abiraterone Unclear - Unclear ABIRATERONE [2]
MR010807 3-keto-Delta4-Abiraterone(D4A) 3-keto-5beta-Abiraterone Unclear - Unclear ABIRATERONE [2]
References
1 Abiraterone for the treatment of metastatic castrate-resistant prostate cancer. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1016-24.
2 The interactions of a number of steroid-metabolizing cytochromes P450 with abiraterone D4A metabolite: spectral analysis and molecular docking

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