Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010843)
Formula
SVG example
Unclear
Reactant Selegiline Product Desmethyl selegiline
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010841 Selegiline Methamphetamine Unclear - Unclear Selegiline [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002889 Selegiline hydrochloride Desmethylselegiline Oxidation - N-Dealkylation Selegiline hydrochloride [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010844 Desmethyl selegiline Amphetamine Unclear - Unclear Selegiline [1]
MR002892 Desmethylselegiline Levamfetamine Unclear Selegiline hydrochloride [2]
References
1 Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations
2 Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. Drug Metab Dispos. 2003 Sep;31(9):1093-102.
3 Detection of l-Methamphetamine and l-Amphetamine as Selegiline Metabolites. J Anal Toxicol. 2021 Feb 6;45(1):99-104. doi: 10.1093/jat/bkaa058.

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