Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010932)
Formula
SVG example
Unclear
Reactant Lenvatinib Product Lenvatinib N-oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010934 Lenvatinib N-descyclopropyl lenvatinib Unclear - Unclear Lenvatinib [1]
MR010933 Lenvatinib O-demethyl Lenvatinib Unclear - Unclear Lenvatinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001440 Lenvatinib mesylate Lenvatinib mesylate metabolite M3 Oxidation - N-Oxidation Lenvatinib mesylate [2]
References
1 The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib
2 Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison Invest New Drugs. 2016 Jun;34(3):300-18. doi: 10.1007/s10637-016-0342-y.

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