Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010934)
Formula
CYP2B6 ...
SVG example
Unclear
Reactant Lenvatinib Product N-descyclopropyl lenvatinib
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010932 Lenvatinib Lenvatinib N-oxide Unclear - Unclear Lenvatinib [1]
MR010933 Lenvatinib O-demethyl Lenvatinib Unclear - Unclear Lenvatinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001439 Lenvatinib mesylate Lenvatinib mesylate metabolite M1 Oxidation - Dealkylation Lenvatinib mesylate [2]
References
1 The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib
2 Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison Invest New Drugs. 2016 Jun;34(3):300-18. doi: 10.1007/s10637-016-0342-y.

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