Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011201)
Formula
SVG example
O-demethylation
Reactant Hydrocodone Product Hydromorphone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011212 Hydrocodone Hydrocodol Reduction - Ketone reduction Hydrocodone [1]
MR011210 Hydrocodone Hydrocodone M272 Multi-steps Reaction - N-demethylation; O-demethylation Hydrocodone [1]
MR011218 Hydrocodone Hydrocodone N-oxide-1 Oxidation - N-oxidation Hydrocodone [1]
MR011205 Hydrocodone Norhydrocodone Oxidation - N-demethylation Hydrocodone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005109 Hydrocodone bitartrate Hydromorphone Oxidation - O-demethylation Hydrocodone bitartrate [2]
References
1 Update on hydrocodone metabolites in rats and dogs aided with a semi-automatic software for metabolite identification Mass-MetaSite
2 CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. Br J Clin Pharmacol. 2004 Mar;57(3):287-97.

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