Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011205)
Formula
SVG example
N-demethylation
Reactant Hydrocodone Product Norhydrocodone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011212 Hydrocodone Hydrocodol Reduction - Ketone reduction Hydrocodone [1]
MR011210 Hydrocodone Hydrocodone M272 Multi-steps Reaction - N-demethylation; O-demethylation Hydrocodone [1]
MR011218 Hydrocodone Hydrocodone N-oxide-1 Oxidation - N-oxidation Hydrocodone [1]
MR011201 Hydrocodone Hydromorphone Oxidation - O-demethylation Hydrocodone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005123 Hydrocodone bitartrate Norhydrocodone Oxidation - N-demethylation Hydrocodone bitartrate [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011206 Norhydrocodone Hydrocodone M272 Multi-steps Reaction - N-demethylation; O-demethylation Hydrocodone [1]
MR011217 Norhydrocodone Norhydrocodol Reduction - Ketone reduction Hydrocodone [1]
References
1 Update on hydrocodone metabolites in rats and dogs aided with a semi-automatic software for metabolite identification Mass-MetaSite
2 CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. Br J Clin Pharmacol. 2004 Mar;57(3):287-97.

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