Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011407)
Formula Reactant ITI-007 Product ICI200131
Reactant Info Product Info
Metabolic Enzyme Aldo-keto reductases (AKR) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011408 ITI-007 IC200161 Oxidation - Dealkylation ITI-007 [1]
MR011409 ITI-007 IC200565 Oxidation - Dealkylation ITI-007 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010266 Lumateperone tosylate ICI200131 Unclear - Unclear lumateperone tosylate [1]
MR014073 Lumateperone tosylate ICI200131 Reduction - Reduction lumateperone tosylate [2]
References
1 An evaluation of lumateperone tosylate for the treatment of schizophrenia
2 Dopamine D(2) receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia

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