Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011428)
Formula Reactant Desmethyl futibatinib Product Reduction of Desmethyl futibatinib
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011427 TAS-120 Desmethyl futibatinib Unclear - Unclear TAS-120 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011430 Desmethyl futibatinib Glucuronide of Desmethyl futibatinib Conjugation - Glucuronidation TAS-120 [1]
MR011429 Desmethyl futibatinib Sulfate Desmethyl futibatinib Conjugation - Sulfation TAS-120 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011432 Reduction of Desmethyl futibatinib Reduction hydrolysed desmethyl futibatinib Other reaction - Hydration TAS-120 [1]
MR011431 Reduction of Desmethyl futibatinib Reduction of bisdesmethyl futibatinib Oxidation - O-demethylation TAS-120 [1]
References
1 Evaluation of the Mass Balance and Metabolic Profile of Futibatinib in Healthy Participants

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