Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011438)
Formula Reactant TAS-120 Product Monohydroxy futibatinib
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011427 TAS-120 Desmethyl futibatinib Unclear - Unclear TAS-120 [1]
MR011434 TAS-120 Possible intermediate metabolite Oxidation - Oxidation TAS-120 [1]
MR011423 TAS-120 TAS-120 Metabolite F18 Conjugation - Glutathione conjugation TAS-120 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011441 Monohydroxy futibatinib Cysteine-conjugated monohydroxyl futibatinib Unclear - Unclear TAS-120 [1]
MR011440 Monohydroxy futibatinib Sulfate Monohydroxy futibatinib Conjugation - Sulfation TAS-120 [1]
MR011439 Monohydroxy futibatinib TAS-120 Metabolite P1 Conjugation - Glucuronidation TAS-120 [1]
References
1 Evaluation of the Mass Balance and Metabolic Profile of Futibatinib in Healthy Participants

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