Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011606)
Formula Reactant Tivantinib Metabolite M4 Product Tivantinib Metabolite M11
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011603 Tivantinib Tivantinib Metabolite M4 Unclear - Unclear Tivantinib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011605 Tivantinib Metabolite M4 Tivantinib Metabolite M15,16 Unclear - Unclear Tivantinib [1]
MR011604 Tivantinib Metabolite M4 Tivantinib Metabolite M6 Unclear - Unclear Tivantinib [1]
References
1 Stereoselective hydroxylation by CYP2C19 and oxidation by ADH4 in the in vitro metabolism of tivantinib

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