Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011694)
Formula
SVG example
Unclear
Reactant Benzisothiazol-3-yl-piperazin (BITP) Product BITP-O(BMY-40729)
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006933 Lurasidone ID-11614 Unclear Lurasidone [1]
MR013365 M-813 ID-11614 Unclear M-813 [2]
MR011693 TIOSPIRONE Benzisothiazol-3-yl-piperazin (BITP) Unclear - Unclear TIOSPIRONE [3]
MR005684 Ziprasidone 3-(piperazine-1-yl)-1,2-benzisothiazole Oxidation - Oxidationn N-dealkylation Ziprasidone [4]
MR013364 M-813 Metabolite MX1 ID-11614 Unclear M-813 [5]
MR013357 M-813 Metabolite MX11 ID-11614 Unclear M-813 [2]
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Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013358 ID-11614 ID15002 Unclear M-813 [5]
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Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005686 3-(piperazine-1-yl)-1,2-benzisothiazole sulfoxide 3-(piperazine-1-yl)-1,2-benzisothiazole sulfone Oxidation - Oxidationn Ziprasidone [4]
References
1 Pharmacokinetics and pharmacodynamics of lurasidone hydrochloride, a second-generation antipsychotic: a systematic review of the published literature. Clin Pharmacokinet. 2017 May;56(5):493-503.
2 The wide variability of perospirone metabolism and the effect of perospirone on prolactin in psychiatric patients
3 Characterization of in vitro metabolites of the antipsychotic drug tiospirone by mass spectrometry
4 Metabolism and excretion of a new antipsychotic drug, ziprasidone, in humans
5 In vitro metabolism of perospirone in rat, monkey and human liver microsomes

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