Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013365)
Formula
CYP2C8 ...
SVG example
Reactant M-813 Product ID-11614
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013355 M-813 Hydroxyperospirone Oxidation - Hydrolyzationn M-813 [1], [2]
MR013368 M-813 ID-11926 Unclear M-813 [2]
MR013366 M-813 ID-15010 Unclear M-813 [2]
MR013363 M-813 M-813 Metabolite MX1 Unclear M-813 [3], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006933 Lurasidone ID-11614 Unclear Lurasidone [4]
MR011693 TIOSPIRONE Benzisothiazol-3-yl-piperazin (BITP) Unclear - Unclear TIOSPIRONE [5]
MR005684 Ziprasidone 3-(piperazine-1-yl)-1,2-benzisothiazole Oxidation - Oxidationn N-dealkylation Ziprasidone [6]
MR013364 M-813 Metabolite MX1 ID-11614 Unclear M-813 [3]
MR013357 M-813 Metabolite MX11 ID-11614 Unclear M-813 [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005685 3-(piperazine-1-yl)-1,2-benzisothiazole 3-(piperazine-1-yl)-1,2-benzisothiazole sulfoxide Oxidation - Oxidationn Ziprasidone [6]
MR011694 Benzisothiazol-3-yl-piperazin (BITP) BITP-O(BMY-40729) Unclear - Unclear TIOSPIRONE [5]
MR013358 ID-11614 ID15002 Unclear M-813 [3]
References
1 Steady-state pharmacokinetics of a new antipsychotic agent perospirone and its active metabolite, and its relationship with prolactin response. Ther Drug Monit. 2004 Aug;26(4):361-5.
2 The wide variability of perospirone metabolism and the effect of perospirone on prolactin in psychiatric patients
3 In vitro metabolism of perospirone in rat, monkey and human liver microsomes
4 Pharmacokinetics and pharmacodynamics of lurasidone hydrochloride, a second-generation antipsychotic: a systematic review of the published literature. Clin Pharmacokinet. 2017 May;56(5):493-503.
5 Characterization of in vitro metabolites of the antipsychotic drug tiospirone by mass spectrometry
6 Metabolism and excretion of a new antipsychotic drug, ziprasidone, in humans

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.