Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005684)
Formula
SVG example
Oxidationn N-dealkylation
Reactant Ziprasidone Product 3-(piperazine-1-yl)-1,2-benzisothiazole
Reactant Info Product Info
Metabolic Type Oxidation - Oxidationn N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005690 Ziprasidone (6-chloro-2-oxo-2,3-dihydro-1H-indol-5-yl)acetic acid Oxidation - Oxidationn N-dealkylation Ziprasidone [1]
MR005694 Ziprasidone 6-chloro-5-(2-piperazin-1-yl-ethyl)-1,3-dihydro-indol-2-one Other reaction - Deacylation Ziprasidone [1]
MR005695 Ziprasidone Dihydro-ziprasidone-sulfone Multi-steps Reaction - Hydration; oxidation Ziprasidone [1]
MR005692 Ziprasidone S-Methyl-dihydro-ziprasidone Multi-steps Reaction - Methylationn; reductive cleavage Ziprasidone [1]
MR005688 Ziprasidone Ziprasidone Sulfoxide Oxidation - Oxidationn Ziprasidone [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006933 Lurasidone ID-11614 Unclear Lurasidone [3]
MR013365 M-813 ID-11614 Unclear M-813 [4]
MR011693 TIOSPIRONE Benzisothiazol-3-yl-piperazin (BITP) Unclear - Unclear TIOSPIRONE [5]
MR013364 M-813 Metabolite MX1 ID-11614 Unclear M-813 [6]
MR013357 M-813 Metabolite MX11 ID-11614 Unclear M-813 [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005685 3-(piperazine-1-yl)-1,2-benzisothiazole 3-(piperazine-1-yl)-1,2-benzisothiazole sulfoxide Oxidation - Oxidationn Ziprasidone [1]
MR011694 Benzisothiazol-3-yl-piperazin (BITP) BITP-O(BMY-40729) Unclear - Unclear TIOSPIRONE [5]
MR013358 ID-11614 ID15002 Unclear M-813 [6]
References
1 Metabolism and excretion of a new antipsychotic drug, ziprasidone, in humans
2 [Limits of jaw orthopedic treatment]
3 Pharmacokinetics and pharmacodynamics of lurasidone hydrochloride, a second-generation antipsychotic: a systematic review of the published literature. Clin Pharmacokinet. 2017 May;56(5):493-503.
4 The wide variability of perospirone metabolism and the effect of perospirone on prolactin in psychiatric patients
5 Characterization of in vitro metabolites of the antipsychotic drug tiospirone by mass spectrometry
6 In vitro metabolism of perospirone in rat, monkey and human liver microsomes

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