Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013358)
Formula Reactant ID-11614 Product ID15002
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006933 Lurasidone ID-11614 Unclear Lurasidone [1]
MR013365 M-813 ID-11614 Unclear M-813 [2]
MR011693 TIOSPIRONE Benzisothiazol-3-yl-piperazin (BITP) Unclear - Unclear TIOSPIRONE [3]
MR005684 Ziprasidone 3-(piperazine-1-yl)-1,2-benzisothiazole Oxidation - Oxidationn N-dealkylation Ziprasidone [4]
MR013364 M-813 Metabolite MX1 ID-11614 Unclear M-813 [5]
MR013357 M-813 Metabolite MX11 ID-11614 Unclear M-813 [2]
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Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005685 3-(piperazine-1-yl)-1,2-benzisothiazole 3-(piperazine-1-yl)-1,2-benzisothiazole sulfoxide Oxidation - Oxidationn Ziprasidone [4]
MR011694 Benzisothiazol-3-yl-piperazin (BITP) BITP-O(BMY-40729) Unclear - Unclear TIOSPIRONE [3]
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Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013359 ID15002 ID15001 Unclear M-813 [5]
References
1 Pharmacokinetics and pharmacodynamics of lurasidone hydrochloride, a second-generation antipsychotic: a systematic review of the published literature. Clin Pharmacokinet. 2017 May;56(5):493-503.
2 The wide variability of perospirone metabolism and the effect of perospirone on prolactin in psychiatric patients
3 Characterization of in vitro metabolites of the antipsychotic drug tiospirone by mass spectrometry
4 Metabolism and excretion of a new antipsychotic drug, ziprasidone, in humans
5 In vitro metabolism of perospirone in rat, monkey and human liver microsomes

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