Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011750)
Formula
UGT1A4 ...
SVG example
Unclear
Reactant PF-06463922 Product PF-06895751 (M8)
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011762 PF-06463922 PF-06463922 Metabolite M15 Unclear - Unclear PF-06463922 [1]
MR011763 PF-06463922 PF-06463922 Metabolite M1a Unclear - Unclear PF-06463922 [1]
MR011755 PF-06463922 PF-06463922 Metabolite M2a Unclear - Unclear PF-06463922 [1]
MR011761 PF-06463922 PF-06463922 Metabolite M4a Unclear - Unclear PF-06463922 [1]
MR011759 PF-06463922 PF-06463922 Metabolite M5 Unclear - Unclear PF-06463922 [1]
MR011757 PF-06463922 PF-06463922 Metabolite M6 Unclear - Unclear PF-06463922 [1]
MR011752 PF-06463922 PF-06898840 Unclear - Unclear PF-06463922 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006912 Lorlatinib Lorlatinib benzoic acid metabolite (M8) Oxidation - Oxidationn cleavage Lorlatinib [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011751 PF-06895751 (M8) PF-06811569 Unclear - Unclear PF-06463922 [1]
References
1 The Effect of Modafinil on the Safety and Pharmacokinetics of Lorlatinib: A Phase I Study in Healthy Participants
2 #N/A

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