Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006912)
Formula
CYP3A4 ...
SVG example
Oxidationn cleavage
Reactant Lorlatinib Product Lorlatinib benzoic acid metabolite (M8)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
Metabolic Type Oxidation - Oxidationn cleavage
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011750 PF-06463922 PF-06895751 (M8) Unclear - Unclear PF-06463922 [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011751 PF-06895751 (M8) PF-06811569 Unclear - Unclear PF-06463922 [1]
References
1 The Effect of Modafinil on the Safety and Pharmacokinetics of Lorlatinib: A Phase I Study in Healthy Participants

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