Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012143)
Formula	Hydrolysis
	Reactant	Etirinotecan pegol	Product	Irinotecan
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Hydrolysis - Hydrolysis

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR014205	NUC?1031	Gemcitabine	Hydrolysis - Hydrolyzation	acelarin	[1]

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR012146	Irinotecan	APC,NPC	Oxidation - Oxidation	Etirinotecan pegol	[2]
MR012144	Irinotecan	SN-38	Unclear - Unclear	Etirinotecan pegol	[2]

References
1	Anti-tumour activity of a first-in-class agent NUC-1031 in patients with advanced cancer: results of a phase I study
2	Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors

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