Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012146)
Formula Reactant Irinotecan Product APC,NPC
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012143 Etirinotecan pegol Irinotecan Hydrolysis - Hydrolysis Etirinotecan pegol [1]
MR014205 NUC?1031 Gemcitabine Hydrolysis - Hydrolyzation acelarin [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012144 Irinotecan SN-38 Unclear - Unclear Etirinotecan pegol [1]
References
1 Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors
2 Anti-tumour activity of a first-in-class agent NUC-1031 in patients with advanced cancer: results of a phase I study

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