Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012306)
Formula Reactant LIK-066 Product LIK-066 M13,14
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2J2 (CYP2J2) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012308 LIK-066 LIK-066 M12,15 Multi-steps Reaction - Oxidation; Dioxine oxidation ring opening LIK-066 [1]
MR012315 LIK-066 LIK-066 M17,27 Multi-steps Reaction - Oxidation; direct glucuronidation LIK-066 [1]
MR012311 LIK-066 LIK-066 M20,M21 Multi-steps Reaction - Oxidation; Dioxine oxidation ring opening LIK-066 [1]
MR012303 LIK-066 LIK-066 M22 Oxidation - Oxidation LIK-066 [1]
MR012314 LIK-066 LIK-066 M28 Multi-steps Reaction - Oxidation; Desaturation LIK-066 [1]
MR012313 LIK-066 LIK-066 M7 Multi-steps Reaction - O-dealkylation; Dioxine oxidation ring opening; glucurondation LIK-066 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012307 LIK-066 M13,14 LIK-066 M10,18,41 Conjugation - Glucuronidation LIK-066 [1]
References
1 Pharmacokinetics, metabolism, and excretion of licogliflozin, a dual inhibitor of SGLT1/2, in rats, dogs, and humans

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