Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012487)
Formula Reactant JI-101 Product JI-101 M1
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Dihydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012489 JI-101 JI-101 M3 Oxidation - Monohydroxylation JI-101 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012488 JI-101 M1 JI-101 M2 Oxidation - Monohydroxylation JI-101 [1]
References
1 Pharmacokinetics, tissue distribution and identification of putative metabolites of JI-101 - a novel triple kinase inhibitor in rats

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