Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012974)
Formula Reactant GS-563117 Product Idelalisib Metabolite M20
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012969 Idelalisib GS-563117 Unclear Idelalisib [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012970 GS-563117 Idelalisib Metabolite M19 Unclear Idelalisib [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012975 Idelalisib Metabolite M20 Idelalisib Metabolite M18 Unclear Idelalisib [2]
References
1 Clinical drug interaction profile of idelalisib in healthy subjects
2 Identification of Novel Pathways in Idelalisib Metabolism and Bioactivation

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