Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012991)
Formula Reactant Imipramine hydrochloride Product Didemethylimipramine
Reactant Info Product Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012989 Imipramine hydrochloride 2-hydroxyimipramine Oxidation - 2-hydroxylation Imipramine hydrochloride [1]
MR012986 Imipramine hydrochloride Desipramine Oxidation - N-demethylation Imipramine hydrochloride [2]
MR012994 Imipramine hydrochloride Imidodibenzyl Metabolite Oxidation - N-dealkylation Imipramine hydrochloride [3]
MR012993 Imipramine hydrochloride Imipramine N-oxide Oxidation - N-oxidation Imipramine hydrochloride [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012992 Didemethylimipramine 10-hydroxydidemethylimipramine Oxidation - Hydrolyzationn Imipramine hydrochloride [3]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism. Drug Metab Dispos. 1999 Jan;27(1):102-9.
3 Clinical pharmacokinetics of imipramine and desipramine

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