Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012989)
Formula
CYP1A2 ...
SVG example
2-hydroxylation
Reactant Imipramine hydrochloride Product 2-hydroxyimipramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - 2-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012986 Imipramine hydrochloride Desipramine Oxidation - N-demethylation Imipramine hydrochloride [1]
MR012991 Imipramine hydrochloride Didemethylimipramine Oxidation - Demethylation Imipramine hydrochloride [2]
MR012994 Imipramine hydrochloride Imidodibenzyl Metabolite Oxidation - N-dealkylation Imipramine hydrochloride [2]
MR012993 Imipramine hydrochloride Imipramine N-oxide Oxidation - N-oxidation Imipramine hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012990 2-hydroxyimipramine 2-hydroxy-imipramine glucuronide Conjugation - Glucuronidation Imipramine hydrochloride [3]
References
1 Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism. Drug Metab Dispos. 1999 Jan;27(1):102-9.
2 Clinical pharmacokinetics of imipramine and desipramine
3 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.

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