Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012994)
Formula Reactant Imipramine hydrochloride Product Imidodibenzyl Metabolite
Reactant Info Product Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012989 Imipramine hydrochloride 2-hydroxyimipramine Oxidation - 2-hydroxylation Imipramine hydrochloride [1]
MR012986 Imipramine hydrochloride Desipramine Oxidation - N-demethylation Imipramine hydrochloride [2]
MR012991 Imipramine hydrochloride Didemethylimipramine Oxidation - Demethylation Imipramine hydrochloride [3]
MR012993 Imipramine hydrochloride Imipramine N-oxide Oxidation - N-oxidation Imipramine hydrochloride [3]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism. Drug Metab Dispos. 1999 Jan;27(1):102-9.
3 Clinical pharmacokinetics of imipramine and desipramine

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