Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013084)
Formula
CYP1A1 ...
SVG example
Aromatic hydroxylation
Reactant Zotepine Product 3-OH-zotepine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Aromatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013083 Zotepine 2-OH-zotepine Oxidation - Aromatic hydroxylation Zotepine [1]
MR013081 Zotepine Norzotepine Oxidation - N-demethylation Zotepine [1], [2]
MR013082 Zotepine Zotepine N-oxide Oxidation - N-oxidation Zotepine [1]
MR013085 Zotepine Zotepine S-oxide Oxidation - S-oxidation Zotepine [1]
References
1 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
2 Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake

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