Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013093)
Formula
CYP1A1 ...
SVG example
N-dealkylation
Reactant Amiodarone hydrochloride Product Mono-N-desethylamiodarone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013097 Amiodarone hydrochloride Amiodarone hydrochloride Metabolite M1 Oxidation - O-deakylation Amiodarone hydrochloride [1]
MR013095 Amiodarone hydrochloride Amiodarone hydrochloride Metabolite M2 Oxidation - HYDROXYLATION Amiodarone hydrochloride [1]
MR013098 Amiodarone hydrochloride B2-O-Et-N-dipropyl Reduction - Deiodination Amiodarone hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013094 Mono-N-desethylamiodarone Di-N-desethylamiodarone Unclear - Unclear Amiodarone hydrochloride [1]
References
1 Pharmacology and pharmacokinetics of amiodarone

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