Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013111)
Formula
CYP3A4 ...
SVG example
N-demethylation
Reactant Meperidine Product Normeperidine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013117 Meperidine Meperidine N-oxide Oxidation - N-demethylation Meperidine [1]
MR013115 Meperidine Meperidinic acid Unclear - Unclear Meperidine [1]
MR013118 Meperidine Methoxy-hydroxymeperidine Unclear - Unclear Meperidine [1]
MR013119 Meperidine p-hydrox ymeperidine Unclear - Unclear Meperidine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008722 Anileridine Normeperidine Unclear - Unclear Anileridine [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013113 Normeperidine N-hydroxynormeperidine Unclear - Unclear Meperidine [1]
MR013112 Normeperidine Normeperidinic acid Hydrolysis - Hydrolysis Meperidine [1]
MR008723 Normeperidine p-Aminophenylacetic acid Unclear - Unclear Anileridine [2]
MR013114 Normeperidine p-hydroxynormeperidine Unclear - Unclear Meperidine [1]
References
1 Urinary excretion of meperidine and its metabolites
2 N-dealkylation of anileridine to normeperidine

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