Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013194)
Formula
CYP2D6 ...
SVG example
O-dealkylation
Reactant Umeclidinium bromide Product Umeclidinium M14
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Metabolic Type Oxidation - O-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013189 Umeclidinium bromide Umeclidinium M33 Oxidation - Hydroxylation Umeclidinium bromide [1]
MR013195 Umeclidinium bromide Umeclidinium M37 Oxidation - Hydroxylation Umeclidinium bromide [1]
MR013192 Umeclidinium bromide Umeclidinium M51 Unclear Umeclidinium bromide [1]
MR013196 Umeclidinium bromide Umeclidinium M61 Unclear Umeclidinium bromide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008834 Umeclidinium Umeclidinium M14 Oxidation - O-dealkylation Umeclidinium [2]
References
1 CLINICAL PHARMACOLOGY AND BIOPHARMACEUTICS REVIEW: Umeclidinium Bromide
2 Pharmacokinetics, metabolite profiling, safety, and tolerability of inhalation aerosol of 101BHG-D01, a novel, long-acting and selective muscarinic receptor antagonist, in healthy Chinese subjects

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