Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013356)
Formula Reactant Hydroxyperospirone Product M-813 Metabolite MX11
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013355 M-813 Hydroxyperospirone Oxidation - Hydrolyzationn M-813 [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013361 Hydroxyperospirone M-813 Metabolite MX6 Unclear M-813 [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013357 M-813 Metabolite MX11 ID-11614 Unclear M-813 [2]
MR013360 M-813 Metabolite MX11 M-813 Metabolite MX9 Unclear M-813 [2], [3]
References
1 Steady-state pharmacokinetics of a new antipsychotic agent perospirone and its active metabolite, and its relationship with prolactin response. Ther Drug Monit. 2004 Aug;26(4):361-5.
2 The wide variability of perospirone metabolism and the effect of perospirone on prolactin in psychiatric patients
3 In vitro metabolism of perospirone in rat, monkey and human liver microsomes

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