Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013394)
Formula
SVG example
Esterase hydrolyzation
Reactant Methylphenidate Product Alpha-phenyl-2-piperidine acetic acid (ritalinic acid)
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Metabolic Type Hydrolysis - Esterase hydrolyzation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013369 Methylphenidate 6-Oxo-MPH Unclear Methylphenidate [1]
MR013392 Methylphenidate Carbamide MPH Unclear Methylphenidate [1]
MR013387 Methylphenidate Ethylphenidate Unclear Methylphenidate [1]
MR013383 Methylphenidate p-Hydroxy-MPH Unclear Methylphenidate [1]
MR013382 Methylphenidate Ritalic acid Unclear Methylphenidate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000805 Dexmethylphenidate Ritalinic acid Other reaction - Deesterification Dexmethylphenidate [2]
References
1 Metabolomics of Methylphenidate and Ethylphenidate: Implications in Pharmacological and Toxicological Effects
2 Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. J Pharmacol Exp Ther. 2004 Aug;310(2):469-76.

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