Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013433)
Formula
CYP3A4 ...
SVG example
3'-hydroxylation
Reactant Simvastatin Product Simvastatin hydroxy acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - 3'-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013434 Simvastatin 6'-beta-Hydroxysimvastatin Oxidation - Aliphatic hydroxylation Simvastatin [1]
MR013436 Simvastatin 6-Exomethylenesimvastatin Oxidation - Dehydrogenation Simvastatin [2]
MR013435 Simvastatin Pravastatin 3,5-dihydrodiol Oxidation - Aliphatic hydroxylation Simvastatin [1]
MR013437 Simvastatin Unclear Unclear Simvastatin [2]
References
1 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2 Simvastatin Tablet, Film-Coated

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