Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013434)
Formula
CYP2C8 ...
SVG example
Aliphatic hydroxylation
Reactant Simvastatin Product 6'-beta-Hydroxysimvastatin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Aliphatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013436 Simvastatin 6-Exomethylenesimvastatin Oxidation - Dehydrogenation Simvastatin [1]
MR013435 Simvastatin Pravastatin 3,5-dihydrodiol Oxidation - Aliphatic hydroxylation Simvastatin [2]
MR013433 Simvastatin Simvastatin hydroxy acid Oxidation - 3'-hydroxylation Simvastatin [3]
MR013437 Simvastatin Unclear Unclear Simvastatin [1]
References
1 Simvastatin Tablet, Film-Coated
2 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
3 A comparison of the effects of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro. Drug Metab Dispos. 2001 Mar;29(3):282-8.

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