Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013438)
Formula
SVG example
N-demethylation
Reactant Maprotiline hydrochloride Product Desmethylmaprotiline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013440 Maprotiline hydrochloride 2-OH-maprotiline Oxidation - Aromatic hydroxylation Maprotiline hydrochloride [1]
MR013439 Maprotiline hydrochloride 3-OH-maprotiline Oxidation - Aromatic hydroxylation Maprotiline hydrochloride [1]
References
1 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.

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