Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013531)
Formula
SVG example
Hydrolysis
Reactant Sotorasib Product Sotorasib Metabolite M12
Reactant Info Product Info
Metabolic Enzyme Glutathione S-transferase alpha-1 (GSTA1) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013547 Sotorasib Sotorasib Metabolite M13 Unclear Sotorasib [1]
MR013546 Sotorasib Sotorasib Metabolite M18 Oxidation - Oxidation Sotorasib [1], [2]
MR013542 Sotorasib Sotorasib Metabolite M21 Unclear Sotorasib [1]
MR013539 Sotorasib Sotorasib Metabolite M24 Oxidation - Oxidation Sotorasib [1], [2]
MR013544 Sotorasib Sotorasib Metabolite M9 Unclear Sotorasib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013532 Sotorasib Metabolite M12 Sotorasib Metabolite M30 Hydrolysis - Hydrolysis Sotorasib [1], [2]
References
1 Absorption, Distribution, Metabolism, and Excretion of [(14)C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism
2 Absorption, metabolism and excretion of [(14)C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate

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