Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR013546)
Formula	CYP2C8 Oxidation
	Reactant	Sotorasib		Product	Sotorasib Metabolite M18
	Reactant	Reactant Info		Product	Product Info
Metabolic Enzyme	Cytochrome P450 2C8 (CYP2C8)					DME Info
Metabolic Type	Oxidation - Oxidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR013531	Sotorasib	Sotorasib Metabolite M12	Hydrolysis - Hydrolysis	Sotorasib	[1]
MR013547	Sotorasib	Sotorasib Metabolite M13	Unclear	Sotorasib	[1]
MR013542	Sotorasib	Sotorasib Metabolite M21	Unclear	Sotorasib	[1]
MR013539	Sotorasib	Sotorasib Metabolite M24	Oxidation - Oxidation	Sotorasib	[1], [2]
MR013544	Sotorasib	Sotorasib Metabolite M9	Unclear	Sotorasib	[1]

References
1	Absorption, Distribution, Metabolism, and Excretion of [(14)C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism
2	Absorption, metabolism and excretion of [(14)C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate

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