Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013539)
Formula
SVG example
Oxidation
Reactant Sotorasib Product Sotorasib Metabolite M24
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013531 Sotorasib Sotorasib Metabolite M12 Hydrolysis - Hydrolysis Sotorasib [1]
MR013547 Sotorasib Sotorasib Metabolite M13 Unclear Sotorasib [1]
MR013546 Sotorasib Sotorasib Metabolite M18 Oxidation - Oxidation Sotorasib [1], [2]
MR013542 Sotorasib Sotorasib Metabolite M21 Unclear Sotorasib [1]
MR013544 Sotorasib Sotorasib Metabolite M9 Unclear Sotorasib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013540 Sotorasib Metabolite M24 Sotorasib Metabolite M6 Unclear Sotorasib [1]
References
1 Absorption, Distribution, Metabolism, and Excretion of [(14)C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism
2 Absorption, metabolism and excretion of [(14)C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate

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