Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00042)
Xenobiotics Name
Gemfibrozil
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
3463
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [1]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [4]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [4]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 2C8 (CYP2C8) DME Info IC50 = 4.1 microM [3]
References
1 Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers. Eur J Pharmacol. 2008 Apr 28;584(2-3):213-21.
2 Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
3 Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks. J Med Chem. 2012 Jun 14;55(11):4896-933.
4 Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes. Pharm Res. 2005 Jan;22(1):71-8.

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