Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00094)
Xenobiotics Name
Progesterone
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
5994
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [2]
Alkaline phosphatase (ALPL) DME Info Homo sapiens [3]
Carbonic anhydrase II (CA2) DME Info Homo sapiens [4]
Catechol O-methyltransferase (COMT) DME Info Homo sapiens [5]
Aromatase (CYP19A1) DME Info Homo sapiens [6]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [5]
Calcidiol 1-monooxygenase (CYP27B1) DME Info Homo sapiens [5]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [7]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [8]
Alcohol dehydrogenase class-I gamma (ADH1C) DME Info Homo sapiens [9]
Asparagine synthetase (ASNS) DME Info Homo sapiens [10], [11]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [6]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [12]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [13]
Dipeptidyl peptidase IV (DPP4) DME Info Homo sapiens [10], [14]
Oleamide hydrolase 1 (FAAH) DME Info Homo sapiens [15]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [16]
Hexosephosphate aminotransferase 2 (GFPT2) DME Info Homo sapiens [10]
Gamma-glutamyltranspeptidase 5 (GGT5) DME Info Homo sapiens [17]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [18]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [19]
Neprilysin (MME) DME Info Homo sapiens [10]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [20]
Metallothionein-1A (MT1A) DME Info Homo sapiens [21]
Vitamin B12 methionine synthase (MTR) DME Info Homo sapiens [10]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [22]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [23], [24]
Cytosolic phospholipase A2 (PLA2G4A) DME Info Homo sapiens [18]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [25]
Tryptophan oxygenase (TRPO) DME Info Homo sapiens [10]
Transglutaminase H (TGM2) DME Info Homo sapiens [10]
Thymidylate synthase (TYMS) DME Info Homo sapiens [10], [14]
References
1 Proadifen sensitizes resistant ovarian adenocarcinoma cells to cisplatin. Toxicol Lett. 2016 Jan 22;243:56-66.
2 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
3 Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes. Xenobiotica. 2004 May;34(5):429-38.
4 In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole. Drug Metab Pharmacokinet. 2003;18(5):287-95.
5 Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway. Sci Rep. 2019 Jan 24;9(1):675.
6 Changes in trophoblasts gene expression in response to perchlorate exposition. Toxicol In Vitro. 2018 Aug;50:328-335.
7 Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line. Toxicology. 2006 Nov 10;228(1):98-108.
8 A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4. Drug Metab Dispos. 2008 Dec;36(12):2506-12.
9 Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR. Toxicol Lett. 2015 Feb 3;232(3):580-9.
10 Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem. 2005 Nov 11;280(45):37547-57.
11 Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica. 2009 Nov;39(11):826-35.
12 Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift. Free Radic Biol Med. 2009 Sep 15;47(6):710-21.
13 Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression. J Clin Invest. 2004 Oct;114(8):1146-57.
14 Induction of the UDP-glucuronosyltransferase 1A1 during the perinatal period can cause neurodevelopmental toxicity. Mol Pharmacol. 2016 Sep;90(3):265-74.
15 Different structural requirements of the ligand binding domain of the aryl hydrocarbon receptor for high- and low-affinity ligand binding and receptor activation. Mol Pharmacol. 2004 Feb;65(2):416-25.
16 HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans. Drug Metab Dispos. 2008 Jan;36(1):137-45.
17 Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice. Arch Toxicol. 2017 Aug;91(8):2895-2907.
18 Induction of cyclooxygenase-2 mRNA and protein expression by dentin bonding agents in human gingival fibroblasts. J Biomed Mater Res B Appl Biomater. 2004 Aug 15;70(2):297-302.
19 Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system. Toxicol Sci. 2006 Jun;91(2):501-9.
20 The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2. Environ Toxicol Pharmacol. 2009 Nov;28(3):370-8.
21 Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor. Biol Pharm Bull. 2003 Apr;26(4):510-7.
22 The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion. Mol Endocrinol. 2005 May;19(5):1170-80.
23 Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor. J Pharmacol Exp Ther. 2004 Aug;310(2):528-35.
24 Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer-based virtual screening. J Biol Chem. 2012 Sep 21;287(39):33001-13.
25 Role of adrenoceptor-linked signaling pathways in the regulation of CYP1A1 gene expression. Biochem Pharmacol. 2005 Jan 15;69(2):277-87.

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