Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00177)
Xenobiotics Name
Sulindac
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
1548887
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [2]
N-acetyltransferase 1 (NAT1) DME Info Homo sapiens [3]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [4]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Arachidonate 15-lipoxygenase (ALOX15) DME Info Homo sapiens [5]
Asparagine synthetase (ASNS) DME Info Homo sapiens [5]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [6]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [7]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [6]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [8]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Aldo-keto reductase 1B1 (AKR1B1) DME Info IC50 = 0.374 microM [1]
Prostaglandin G/H synthase 2 (COX-2) DME Info IC50 = 8.8 microM [4]
References
1 Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10. Chem Biol Interact. 2015 Jun 5;234:290-6.
2 High-affinity binding of fatty acyl-CoAs and peroxisome proliferator-CoA esters to glutathione S-transferases effect on enzymatic activity. Eur J Biochem. 1999 Nov;266(1):143-50.
3 A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: application to acetaminophen. Toxicol Appl Pharmacol. 2016 Feb 1;292:40-55.
4 Synthesis and evaluation of novel erlotinib-NSAID conjugates as more comprehensive anticancer agents. ACS Med Chem Lett. 2015 Sep 8;6(10):1086-90.
5 Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation. Food Chem Toxicol. 2017 Nov;109(Pt 1):130-142.
6 Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice. Cancer Prev Res (Phila). 2013 Sep;6(9):886-97.
7 High fat diet-induced hepatic 18-carbon fatty acids accumulation up-regulates CYP2A5/CYP2A6 via NF-E2-related factor 2. Front Pharmacol. 2017 May 15;8:233.
8 CYP3A5 mRNA degradation by nonsense-mediated mRNA decay. Mol Pharmacol. 2005 Sep;68(3):808-15.

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