Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00178)
Xenobiotics Name
Capsaicin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
1548943
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [1]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [1]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [4]
Nitric oxide synthase brain (NOS1) DME Info Homo sapiens [5]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [5]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [5]
Phosphoglucomutase 1 (PGM1) DME Info Homo sapiens [6]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 1A2 (CYP1A2) DME Info IC50 = 3 microM [1]
References
1 Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
2 Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. Int J Toxicol. 2010 Mar;29(2 Suppl):22S-6S.
3 Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target. Antioxid Redox Signal. 2007 Dec;9(12):2087-98.
4 Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
5 Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation. Anticancer Res. 2009 Oct;29(10):3733-40.
6 Capsaicin induced the upregulation of transcriptional and translational expression of glycolytic enzymes related to energy metabolism in human intestinal epithelial cells. J Agric Food Chem. 2009 Dec 9;57(23):11148-53.

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