Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00385)
Xenobiotics Name
Tranylcypromine
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
19493
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [1]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [2]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [2]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 2A6 (CYP2A6) DME Info Ki = 0.13 microM [1]
Cytochrome P450 2B6 (CYP2B6) DME Info IC50 = 6.96 microM [2]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info IC50 = 3.04 microM [2]
References
1 Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes. Drug Metab Dispos. 2012 Sep;40(9):1797-802.
2 Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases. J Med Chem. 2008 Apr 10;51(7):2158-69.

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