Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00591)
Xenobiotics Name
Ditiocarb
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
8987
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [1]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [2]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [2]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [3]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [4]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [5]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 2E1 (CYP2E1) DME Info IC50 = 0.85 microM [3]
References
1 Effects of inhibition of catalase and superoxide dismutase activity on antioxidant enzyme mRNA levels. Am J Physiol. 1993 Dec;265(6 Pt 1):L636-43.
2 Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes. Xenobiotica. 1996 Jul;26(7):681-93.
3 Drug-drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338. Eur J Pharmacol. 2004 Aug 23;497(2):223-31.
4 Species-specific differences in the inhibition of human and zebrafish 11beta-hydroxysteroid dehydrogenase 2 by thiram and organotins. Toxicology. 2012 Nov 15;301(1-3):72-8.
5 Alterations in anti-oxidative defence enzymes in erythrocytes from sporadic amyotrophic lateral sclerosis (SALS) and familial ALS patients. Clin Chem Lab Med. 2006;44(5):589-93.

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