Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01099)
Xenobiotics Name
1-aminobenzotriazole
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Preclinical/Patented Drug
Structure
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3D MOL 2D MOL
PubChem CID
1367
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [1]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [2]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [2]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 2C9 (CYP2C9) DME Info IC50 = 42.9 microM [2]
Cytochrome P450 2D6 (CYP2D6) DME Info IC50 = 10.5 microM [2]
Cytochrome P450 3A4 (CYP3A4) DME Info IC50 = 0.45 microM [2]
References
1 In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole. Drug Metab Pharmacokinet. 2003;18(5):287-95.
2 Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. Bioorg Med Chem Lett. 2001 Dec 3;11(23):2993-5.

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